Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology

Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology

Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology

Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology

Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology

Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology

Radical prostatectomy (RP) vs. radiation therapy (RT) in high-risk prostate cancer (HR-PCa): Randomized comparison emulated with individual patient data (IPD) from two phase III randomized controlled trials (RCTs).

In general, standard of care (SOC) treatment options for high-risk prostate cancer (HR- PCa) include: radiotherapy (RT) with long-term androgen deprivation (LT-ADT) or radical prostatectomy (RP) with selective use of postoperative RT +/- androgen deprivation therapy (ADT). Retrospective population-based and multicenter studies have evaluated the optimal approach but have produced divergent results. Thus, the present study performed an emulated randomized comparison of RT vs. RP in high-risk p

PRESIDENTIAL Study: Evaluation of Enzalutamide in Combination With Chemotherapy in Patients With Metastatic Prostate Cancer

The PRESIDE study was conducted to evaluate the continued efficacy of enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after initial docetaxel therapy. The aim was to determine whether maintaining enzalutamide in combination with subsequent chemotherapy could offer additional benefits compared to chemotherapy alone.The study design was multicenter, randomized, and double-blind. Patients were initially treated with enzalutamide monothe

Usefulness of the two-dimensional echocardiogram in the diagnosis of severe coronary stenosis in patients with acute coronary syndrome without ST-segment elevation

Introduction:Echocardiogram in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) can detect the location and extent of wall motion abnormalities and thus infer the severity of coronary lesions.Objective:

Cardiology